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Surveillance & Monitoring :

Initial Virologic Response and HIV Drug Resistance Among HIV-Infected Individuals Initiating First-line Antiretroviral Therapy at 2 Clinics in Chennai and Mumbai, India

   Human immunodeficiency virus drug resistance (HIVDR) in cohorts of patients initiating antiretroviral therapy (ART) at clinics in Chennai and Mumbai, India, was assessed following World Health rganization (WHO) guidelines. Twelve months after ART initiation, 75% and 64.6% of participants at the Chennai and Mumbai clinics, respectively, achieved viral load suppression of <1000 copies/mL (HIVDR prevention). HIVDR at initiation of ART (P <.05) and 12-month CD4 cell counts <200 cells/mL (P <.05) were associated with HIVDR at 12 months. HIVDR prevention exceeded WHO guidelines (‡70%) at the Chennai clinic but was below the target in Mumbai due to high rates of loss to follow-up. Findings highlight the need for defaulter tracing and scale-up of routine viral load testing to identify patients failing first-line ART.

Reference:

Initial virologic response and HIV drug resistance among HIV-infected individuals initiating first-line antiretroviral therapy at 2 clinics in Chennai and Mumbai, India.
Hingankar NK, Thorat SR, Deshpande A, Rajasekaran S, Chandrasekar C, Kumar S, Srikantiah P, Chaturbhuj DN, Datkar SR, Deshmukh PS, Kulkarni SS, Sane S, Reddy DC, Garg R, Jordan MR, Kabra S, Tripathy SP, Paranjape RS. Clin Infect Dis. 2012 May;54 Suppl 4:S348-54

  •  Mumbai transmitted HIVDR
  •   Kakinada transmitted HIVDR
  •   Chennai and Mumbai HIVDR Monitoring
  •  HIVDR in ARV treated patients
  •  HIVDR in ARV Naive patients
  •   HIVDR studies MTCT program

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